男，漢族，籍貫重慶綦江，中共黨員，博士，碩導(dǎo)。學(xué)科專業(yè)：腎內(nèi)科；研究方向：腎臟病、自身免疫病。聯(lián)系方式：座機:05546621020  QQ：64918771。地址郵編：安徽省淮南市泰豐大街168號醫(yī)學(xué)部，232001；電子郵箱daiyong22@aust.edu.cn 。俄羅斯工程院院士（外籍），腎內(nèi)科主任醫(yī)師、內(nèi)科學(xué)教授、生物醫(yī)學(xué)工程研究員，博士研究生導(dǎo)師。廣東省A類人才。2017年度國家科技進步獎二等獎獲得者，愛思唯爾2020和2021年中國高被引學(xué)者之一，連續(xù)三年入列全球頂尖科學(xué)家，2022年本專業(yè)領(lǐng)域最活躍5位學(xué)者之一。嶺南名醫(yī)。1983 年和1992 年畢業(yè)于同濟醫(yī)科大學(xué)和中山醫(yī)科大學(xué)，獲醫(yī)學(xué)博士學(xué)位。2002-2003 在德國愛爾蘭根大學(xué)（Erlangen-Nuremberg university）作為訪問學(xué)者和博士后工作和學(xué)習(xí)?，F(xiàn)任安徽理工大學(xué)特聘教授、醫(yī)學(xué)部執(zhí)行主任，暨南大學(xué)教授、博士研究生導(dǎo)師，南方科技大學(xué)教授、博士研究生導(dǎo)師，美國貝勒盛威醫(yī)療集團和德州農(nóng)工大學(xué)醫(yī)學(xué)院訪問教授。先后受聘華中科技大學(xué)同濟醫(yī)學(xué)院協(xié)和醫(yī)院腎內(nèi)科兼職教授、博士研究生導(dǎo)師；重慶醫(yī)科大學(xué)醫(yī)學(xué)檢驗系兼職教授、博士研究生導(dǎo)師。承擔(dān)和完成各級研究課題82項；獲國家授權(quán)發(fā)明專利32項；在國內(nèi)外發(fā)表論文796篇，其中被SCI收錄論文291篇，總引用次數(shù)超過6695次，單篇引用最高454次，H指數(shù)38。主編或者參與編寫專著9部，其中4部國外專著；獲科研成果獎28項，其中獲國家科技進步二等獎1項，省部級科研成果獎14項。

腎內(nèi)科

腎臟病、自身免疫病。

[1]以疾病特異誘導(dǎo)多能干細胞為模型探究系統(tǒng)性紅斑狼瘡異常B淋巴細胞中組蛋白修飾的作用機制，國家自然科學(xué)基金面上項目，81671596，2017.01-2020.12，主持

[2]廣東省自身免疫性疾病精準(zhǔn)醫(yī)療工程技術(shù)研究中心，廣東省科技廳工程技術(shù)研究中心，2018.12-至今，主持

[3]廣東省出生缺陷疾病臨床醫(yī)學(xué)研究中心，廣東省科技廳社會發(fā)展領(lǐng)域項目，2017B020209001，2017.01-2019.12，主持

[4]前列腺癌干細胞靶向性T細胞治療技術(shù)平臺，廣東省科技廳粵港聯(lián)合創(chuàng)新領(lǐng)域項目，2016A050503009，2016.07-2018.06，主持

[5]基于Hi-C方法確定SLE-iPSC向樹突狀細胞分化相關(guān)增強子調(diào)控網(wǎng)絡(luò)及機制研究，深圳市科技創(chuàng)新委面上項目，JCYJ20210324113013035，2021.11-2024.10，主持

[6]深圳市自身免疫病工程研究中心，深圳市發(fā)展和改革委員會，2020.07-2022.06，主持

[7]IgA腎病B淋巴細胞抗原受體分布多樣性變異及克隆性增殖分析，深圳市科技創(chuàng)新委面上項目，JCYJ20160422164313440，2016.09-2019.08，主持

[1]Yixi Li, Donge Tang*, Lianghong Yin*, Yong Dai*. New insights for regulatory T cell in lupus nephritis[J]. Autoimmun Rev. 2022, 21(8):103134.

[2]Cantong Zhang, Liancheng Lin, Donge Tang, Fuju Liu, Meng Li, Qiongying Li, Zhaoxiang Deng, Guohai Chu, Dayong Gu*, Yong Dai*. Antibody responses to SARS‐CoV‐2 in healthy individuals returning to Shenzhen[J]. Journal of Medical Virology. 2021, 93 (2): 1154-1157.

[3]Cantong Zhang, Shaoying Huang, Fengping Zheng, Yong Dai*. Controversial treatments: an updated understanding of the coronavirus disease 2019[J]. Journal of medical virology. 2020, 92 (9): 1441-1448.

[4]Honglei Wang, Wujian Peng, Xin Ouyang, Wuxian Li, Yong Dai*. Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus[J]. Translational Research 2012, 160 (3): 198-206.

[5]Weiguo Sui#, Xianliang Hou#, Wenti Che, Jiejing Chen, Minglin Ou, Wen Xue, Yong Dai*. Hematopoietic and mesenchymal stem cell transplantation for severe and refractory systemic lupus erythematosus[J]. Clinical Immunology 2013, 148 (2): 186-197.

[6]Weiguo Sui, Q Yan, SP Xie, HZ Chen, D Li, CX Hu, Wujian Peng, Yong Dai*. Successful Organ Donation From Brain Dead Donors in a Chinese Organ Transplantation Center[J]. American Journal of Transplantation 2011, 11 (10): 2247-2249.

[7]Haiyan Yu#, Xiaoping Hong#, Hongwei Wu, Fengping Zheng, Zhipeng Zeng, Weier Dai, Lianghong Yin, Dongzhou Liu*, Donge Tang*, Yong Dai*. The Chromatin Accessibility Landscape of Peripheral Blood Mononuclear Cells in Patients With Systemic Lupus Erythematosus at Single-Cell Resolution[J]. Frontiers in immunology 2021, 12: 641886-641886 .

[8]Jingquan He, Chiyu Ma, Donge Tang, Shaoyun Zhong, Xiaofang Yuan, Fengping Zheng, Zhipeng Zeng, Yumei Chen, Dongzhou Liu, Xiaoping Hong, Weier Dai, Lianghong Yin, Yong Dai*. Absolute quantification and characterization of oxylipins in lupus nephritis and systemic lupus erythematosus[J]. Front Immunol. 2022, 13:964901.

[9]Zongchao Yu#, Xiaoping Hong#, Xiaoli Zhang#, Fengping Zheng, Fanna Liu, Huixuan Xu, Chengxin Zhu, Wanxia Cai, Dongzhou Liu, Lianghong Yin, Bo Hu*, Donge Tang*, Yong Dai*. Global Proteomic Analyses Reveals Abnormal Immune Regulation in Patients With New Onset Ankylosing Spondylitis[J]. Front Immunol.2022 ,13:838891.

[10]Hongwei Wu#, Jingjing Dong#, Haiyan Yu,Kang Wang,Weier Dai,Xinzhou Zhang,Nan Hu, Lianghong Yin, Donge Tang*,Fanna Liu*, Yong Dai*. Single-Cell RNA and ATAC Sequencing Reveal Hemodialysis-Related Immune Dysregulation of Circulating Immune Cell Subpopulations[J]. Front Immunol. 2022, 13:878226.

[11]Yafang Zhong#, Wei Zhang#, Xiaoping Hong, Zhipeng Zeng, Yumei Chen, Shengyou Liao, Wanxia Cai, Yong Xu, Gang Wang, Dongzhou Liu*, Donge Tang*, Yong Dai*. Screening Biomarkers for Systemic Lupus Erythematosus Based on Machine Learning and Exploring Their Expression Correlations With the Ratios of Various Immune Cells[J]. Front Immunol. 2022, 13:873787.

[12]Huixuan Xu, Haiyan Yu, Lixiong Liu, Hongwei Wu, Cantong Zhang, Wanxia Cai,Xiaoping Hong, Dongzhou Liu *, Donge Tang *，Yong Dai*. Integrative Single-Cell RNA-Seq and ATAC-Seq Analysis of Peripheral Mononuclear Cells in Patients With Ankylosing Spondylitis[J]. Front Immunol. 2021,12:760381.

[13]Jingquan He, Tianlong Chan, Xiaoping Hong, Fengping Zheng, Chengxin Zhu, Lianghong Yin, Weier Dai, Donge Tang*, Dongzhou Liu*, Yong Dai*. Microbiome and Metabolome Analyses Reveal the Disruption of Lipid Metabolism in Systemic Lupus Erythematosus[J]. Frontiers in immunology 2020, 11:1703.

[14]Xiaoping Hong#, Shuhui Meng#, Donge Tang, Tingting Wang, Liping Ding, Haiyan Yu, Heng Li, Dongzhou Liu, Yong Dai*, Min Yang*. Single-Cell RNA Sequencing Reveals the Expansion of Cytotoxic CD4+ T Lymphocytes and a Landscape of Immune Cells in Primary Sjögren’s Syndrome[J]. Front Immunol. 2021, 11: 3688.

[15]Yixi Li, Chiyu Ma, Shengyou Liao, Suwen Qi, Shuhui Meng, Wanxia Cai, Weier Dai, Rui Cao, Xiangnan Dong, Bernhard K Krämer, Chen Yun, Berthold Hocher, Xiaoping Hong, Dongzhou Liu, Donge Tang*, Jingquan He*, Lianghong Yin*, Yong Dai*. Combined proteomics and single cell RNA-sequencing analysis to identify biomarkers of disease diagnosis and disease exacerbation for systemic lupus erythematosus[J]. Front Immunol. 2022, 13:969509.

[16]Wencong Song, Jie Qiu, Lianghong Yin, Xiaoping Hong, Weier Dai, Donge Tang*, Dongzhou Liu*, Yong Dai*. Integrated analysis of competing endogenous RNA networks in peripheral blood mononuclear cells of systemic lupus erythematosus[J]. Journal of translational medicine. 2021, 19 (1): 1-15.

[17]Yongping Lu#, Zepu Zhang#, Hongwei Wu#, Lijing Fang, Bo Hu, Chun Tang, Yiqing Zhang,,Lianghong Yin, Donge Tang, Zhihua Zheng*, Ting Zhu*, Yong Dai*. SGLT2 inhibitors improve kidney function and morphology by regulating renal metabolic reprogramming in mice with diabetic kidney disease[J]. J Transl Med. 2022, 14;20(1):420.

[18]Shuhui Meng, Teng Li, Tingting Wang, Dandan Li, Jieping Chen, Heng Li, Wanxia Cai, Zhipeng Zeng, Dongzhou Liu, Donge Tang*, Xiaoping Hong*, Yong Dai*. Global Phosphoproteomics Unveils Kinase-Regulated Networks in Systemic Lupus Erythematosus[J]. Mol Cell Proteomics. 2022, 21(12):100434.

[19]Ting Luo#, Fengping Zheng#, Kang Wang, Yong Xu, Huixuan Xu, Wenxi Shen, Chengxin Zhu,Xinzhou Zhang, Weiguo Sui, Donge Tang*, Lianghong Yin*,Yong Dai*. A single-cell map for the transcriptomic signatures of peripheral blood mononuclear cells in end-stage renal disease[J]. Nephrol Dial Transplant. 2021,36(4):599-608.

[20]Yongping Lu, Hongwei Wu, Ting Zhu, Xitong Li, Jiao Zuo, Ahmed A Hasan, Christoph Reichetzeder, Denis Delic, Benito Yard, Thomas Klein, Bernhard K Krämer, Zeyu Zhang, Xiaohua Wang, Lianghong Yin, Yong Dai*, Zhihua Zheng*, Berthold Hocher*. Empagliflozin reduces kidney fibrosis and improves kidney function by alternative macrophage activation in rats with 5/6-nephrectomy[J]. Biomed Pharmacother. 2022,156:113947.

[21]Hongwei Wu#, Donge Tang#, Manhua Yun, Haiping Liu, Shaoxing Huang, Chen Yun, Berthold Hocher, Xinzhou Zhang, Fanna Liu*, Lianghong Yin*, Yong Dai*. Metabolic Dysfunctions of Intestinal Fatty Acids and Tryptophan Reveal Immuno-Inflammatory Response Activation in IgA Nephropathy[J]. Front Med (Lausanne).2022 Feb 3;9:811526.

[22]Xianliang Hou#, Xiaoping Hong#, Minglin Ou#, Shuhui Meng, Tingting Wang, Shengyou Liao, Jingquan He, Haiyan Yu, Lixiong Liu, Lianghong Yin, Dongzhou Liu*, Donge Tang*, Yong Dai*. Analysis of Gene Expression and TCR/B Cell Receptor Profiling of Immune Cells in Primary Sjögren's Syndrome by Single-Cell Sequencing[J]. J Immunol. 2022, 209(2):238-249.

[23]Jiayi Liu, Yu Shangguan, Donge Tang*, Yong Dai*. Histone succinylation and its function on the nucleosome[J]. Journal of Cellular and Molecular Medicine 2021, 25 (15): 7101-7109.

[24]Fengping Zheng, Huixuan Xu, Cantong Zhang, Xiaoping Hong, Dongzhou Liu, Donge Tang*, Zuying Xiong*, Yong Dai*. Immune cell and TCR/BCR repertoire profiling in systemic lupus erythematosus patients by single-cell sequencing[J]. Aging (Albany NY). 2021,13(21):24432-24448.

[25]Yumei Chen, Chiyu Ma, Lixiong Liu, Jingquan He, Chengxin Zhu, Fengping Zheng,Weier Dai, Xiaoping Hong, Dongzhou Liu*, Donge Tang*, Yong Dai*. Analysis of gut microbiota and metabolites in patients with rheumatoid arthritis and identification of potential biomarkers[J]. Aging (Albany NY). 2021,13(20):23689-23701.

[26]Shaoying Huang, Fengping Zheng, Hua Lin, Xianqing Zhou, Huixuan Xu, Cantong Zhang, Weier Dai, Berthold Hocher, Xinzhou Zhang*, Donge Tang*,Yong Dai*. Quantitative proteomics analysis of lysine 2-hydroxyisobutyrylation in IgA nephropathy[J]. Clin Proteomics. 2021, 18(1):7.

[27]Wencong Song, Donge Tang, Deheng Chen, Fengping Zheng, Shaoying Huang, Yong Xu, Haiyan Yu, Jingquan He, Xiaoping Hong, Lianghong Yin, Dongzhou Liu*, Weier Dai*, Yong Dai*. Advances in applying of multi-omics approaches in the research of systemic lupus erythematosus: Summarization of biomarkers from different omics, and discussion of challenges and advances in integrative analysis of multi-omics in SLE studies[J]. International reviews of immunology 2020, 39 (4): 163-173.